Lacosamide formerly known as erlosamide is a medication for the adjunctive treatment of diabetic neuropathic pain.

Lacosamide acts by enhancing slow inactivation of voltage gated sodium channels. Voltage gated sodium channels are the membrane proteins responsible for generating the neuronal action potential, the all or none electrical event which causes neurons to release neurotransmitter. During an action potential voltage gated sodium channels undergo fast inactivation, a process which takes a few milliseconds. This inactivation prevents the channel from opening, and helps end the action potential.

 

 

 

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